Da-Yong Lu, Jin-Yu Che, Nagendra Sastry Yarla, Hong-Ying Wu, D Lisa, Ting-Ren Lu1 and Hong Zhu
Diabetes Mellitus (DM) is an old disease (Diabetes) in China (over two thousand years) but modern epidemics in western medicines (approximately 100 years). Despite some DM treatment advances, causality, pathogenesis and therapeutics of diabetes is currently too complicated to be easily managed in the clinic. Disease complications (cardiovascular symptoms, vision impairments, nephropathies, chronic leg infections and so on) are more fatal than anti-diabetic control. More importantly, different doctors and pharmaceutical companies often hold different views on DM treatments. To systematically compare between different forms of anti-diabetic therapeutics, new ideas, drug development pipelines, experimental/clinical model establishments and possible future directions are highlighted in this mini-review.
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