Robert Memba
Background: Several studies have suggested a link between microbiota imbalance and a few gastrointestinal, inflammatory and neoplastic diseases. However, the role in pancreatic diseases remains unclear. to guage the available evidence for pancreatic diseases, we undertook a scientific review. Methods: OVID Medline (1946 to 2017), EMBASE (1980 to 2017) and therefore the Cochrane Central Register of Controlled Trials (CENTRAL Issue 3, 2017) were explore for studies on microbiota in pancreatic disease. We also searched the reference lists of retrieved papers and conference proceedings. We excluded animal studies, reviews, and case reports. Results: a complete of two,833 articles were retrieved. After screening and applying the exclusion criteria, 10 studies were included. Three studies showed lower levels of Bifidobacterium or Lactobacillus and better levels of Enterobacteriaceae in chronic pancreatitis. Two of those studies were uncontrolled, and also the third (controlled) study which compared patients with endocrine and exocrine insufficiency, reported that Bacteroidetes levels were lower in those patients without diabetes, while Bifidobacteria levels were higher in those without exocrine insufficiency. only 1 study investigated acute pancreatitis, showing higher levels of Enterococcus and lower levels of Bifidobacterium versus healthy participants. There was an overall association between carcinoma and lower levels of Neisseria elongate, Streptococcus mitis and better levels of Porphyromonas gingivalis and Granulicatella adiacens. Conclusions: Current evidence suggests a possible link between microbiota imbalance and carcinoma. Regarding acute and chronic pancreatitis, data are scarce, dysbiosis appears to be present in both conditions. However, further investigation is required to substantiate these findings and to explore therapeutic possibilities.
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