Khodadoostan Mahsa
Background: Upper gastrointestinal bleeding due to peptic ulcer disease is one of the most common emergencies that gastroenterologists encounter. The aim of this study is evaluating the effect of local Tranexamic Acid via endoscopic procedure for control of peptic ulceration bleeding. Materials and Method: during this study, 100 eligible patients with upper GI bleeding thanks to peptic ulcers enrolled and divided to 2 equal groups: within the first group epinephrine injection plus Argon Plasma Coagulation applied as standard treatment (control group), in the second group Tranexamic Acid solution sprayed in addition to standard treatment(intervention group). Estimated blood loss volume, the need of transfusion , hemoglobin drop, vital sign , pulse , got to the second endoscopy, deathrate , got to surgery, admission duration, and drug effectiveness regarding the ulcer location (duodenum or stomach) were evaluated in both groups and the differences expressed statistically. Results: The mean average ages of intervention and control groups were
62.819.6 and 63.117.8, yrs respectively estimated blood loss
and need for transfusion were lower in the intervention group compared with the control group (p-value 0.05) Conclusion: Tranexamic Acid is a useful additive treatment for control of upper gastrointestinal bleeding and can be used in addition to standard treatment
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