Shamsi Ansari*
Post-traumatic epileptogenesis (PTE) refers to the process by which a traumatic brain injury (TBI) leads to the development of epilepsy. Identifying reliable biomarkers for PTE is crucial for early detection, prognosis, and personalized treatment strategies. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have emerged as promising candidates for biomarker discovery in PTE. This article provides an overview of the role of miRNAs in PTE and discusses their potential as biomarkers for predicting epileptogenesis following TBI. Key findings from preclinical and clinical studies investigating miRNA expression changes in TBI-induced epileptogenesis are summarized, highlighting their diagnostic and prognostic utility. Furthermore, challenges and future directions in miRNA biomarker research for PTE are discussed, emphasizing the importance of translational efforts to harness the full potential of miRNAs in clinical practice.
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