Mukesh Tiwari and Vikram Khanna
Introduction: Even as early as 1916 it was suggested that the nitric oxide is synthetized in the mammals. This nitric oxide, synthetized in the body, was responsible for vasodilation by the endothelium derived relaxing factors and also by the stimulation of the guanylyl cyclase. Inflammatory conditions increase the production of nitrates and nitrites which is seen in the response to endotoxin and is accompanied with nitrosamine formation. Nitric oxide, hence, has been thought to be the physiological messenger and is increases in the pathological processes. This present study was conducted to find the association between the urinary secretion of nitrates and the osteoarthritis. Design: A total of 200 patients coming to the hospital out of 100 were patients with osteoarthritis of the knee joint and 100 were randomly selected. All the patients were screened for the causes of secondary osteoarthritis. Urine sample from all the patients was obtained along with X-ray of bilateral knees was taken to assess the grade of osteoarthritis. The osteoarthritic patients were assigned Group A and the randomly chosen patients were assigned the Group B. Both groups were compared and the results were evaluated. Results: In group A there were 5 cases with urinary nitrate positive as compared to 4 cases with positive urinary nitrate in group B, which was not statistically significant (p > 0.05). Conclusion: The current study clearly shows that there is no association between the urinary nitrate levels and OA.
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