माइक्रोबायोलॉजी और पैथोलॉजी जर्नल

The rise and spread of medication safe microorganisms that have procured new opposition components, prompting antimicrobial obstruction, keeps on compromising our capacity to treat basic contaminations. Particularly disturbing is the quick worldwide spread of multi-and container safe microscopic organisms (otherwise called "superbugs") that cause diseases that are not treatable with existing antimicrobial prescriptions like anti-microbials.

Podocytes keep up the glomerular filtration obstruction, and the solidness of this boundary relies upon their exceptionally separated postmitotic aggregate, which likewise characterizes the specific weakness of the glomerulus. Ongoing podocyte science and quality disturbance concentrates in vivo show a causal connection between anomalies of single podocyte particles and proteinuria and glomerulosclerosis. Podocytes live under different burdens and neurotic upgrades. They adjust to look after homeostasis, however extreme pressure prompts maladaptation with complex natural changes including loss of uprightness and dysregulation of cell digestion. Podocyte injury causes proteinuria and separation from the glomerular storm cellar layer. Notwithstanding "debilitated" podocytes and their separation, our comprehension of glomerular reactions following podocyte misfortune needs to address the pathways from podocyte injury to sclerosis. Studies have discovered an assortment of glomerular reactions to podocyte brokenness in vivo, for example, disturbance of podocyte-endothelial cross talk and initiation of podocyte-parietal cell associations, all of which assist us with understanding the mind boggling situation of podocyte injury and its outcomes. This audit centers around the cell parts of podocyte brokenness and the versatile or maladaptive glomerular reactions to podocyte injury that lead to its significant outcome, glomerulosclerosis.

Quantification of protein and their related enzymes was studied in Lentil (lens culinaris medic) infected with Fusarium oxysporum F. Sp. lentis causing wilt disease. The contents of total protein and protease activities in healthy and diseased counter parts of lentils were measured. Different plant parts showed variation in their protein contents were recorded higher in wilt infected plant then healthy leaf, stem, fruit and seeds while protiase activities were recorded higher in normal leaf, stem, fruit and seeds as compared to infected plant. 

Rhizobia are known to have specificity for their leguminous host . bambara groundnut although a legume has shown promiscuous ability nodulating with many Rhizobia spp. Bradhyrhizobia spp were recovered from selected Nigerian soils by trapping them in the nodules of Bambara groundnut(BG) using pot hose experiments. They were isolated from the nodules and authenticated in the screen house and on the field and six strains along-side USDA110 (control) were selected after they were found to be highly effective and efficient. The DNA was exyracted and Pcr was carried out to check for the presence of Nod A, NodB, NodzA and  NodzB genes. Nod A and Nod B which are conserved in all Rhizobia spp were found to be present. NodzA was found to be present in five of them while Nodz B was found to be present in all six of them. NodzA and Nodz B which are functional genes in soybean symbiointic Rhizobia strains this therefore suggests that BG symbiotic rhizobia strains may be able to nodulate soybean legumes and that NodzA and  Nodz B may possibly play a major role in the nodulation process of BG.

In the tropical and subtropical area, dengue virus is mostly found. To the determination of the occurrence of dengue viral infection and hematological profile of dengue infected peoples in the Dhaka city. A sum of 255 samples of blood from both sex and different age groups were collected in this research. Dengue nonstructural protein 1 (NS1) and complete blood count (CBC) test were performed for the study. During this study period, total 255 samples were tested. Among these, 67samples were diagnosed as positive. Seroprevalence of dengue was 26.30%. Out of 67 positive dengue patients, 41 (61.2 %) were male and 26 (38.8 %) were female. Dengue infection was observed more in 21 to 30years age group followed by above 40years and 16 to 20years but observed less in of 1^st day to 5years followed by 11 -15years, then 6 -10years and 31 - 40years. It was seen that the >40years of age group had the  maximum unit of cases having low platelet count followed by 21-30years and  it was also seen that 21-30years of age group had the maximum range of cases having low WBC count followed by above 40years of age group. In our research, we showed thrombocytopenia (100000 - 150,000/μl) with leucopenia (White Blood Cells, WBC <5000/μl) in 8(26.6%) cases and thrombocytopenia (100000-150,000/μl) without leucopenia in 9 (24.3%) cases but thrombocytopenia (<100000/μl) with leucopenia (White Blood Cells (WBC) < 5000/μl) in 5(16.7%) cases and thrombocytopenia (<100000/μl) without leucopenia in 6 (16.2%) cases. Among 67 positive cases, we found that (26.6%) had DF and (16.7%) had DHF according to WHO classification. For validating more reliability, this research needs further work.