आणविक और आनुवंशिक चिकित्सा

The Impact of Parkin as a Possible Future Biomarker in Five Solid Pediatric Tumors

Abstract

De Castro EM, Souza CM, Percicote AP, Taques GR, Zanoni A, Poncio L, Werner B, Pereira IRPD, De Souza SB, Rocha RMCM, De Franca N, Benevides APK, De Dalke DBZ, Da Camargo CCVS, Esposito SE, Sotomaior VS and De Noronha L

Pediatric neoplasms represent an important group of childhood diseases. Biomarkers with prognostic function can help to manage this complex process. In this context, the tissue expression of parkin, could be used as a prognostic biomarker for the individual in the main solid pediatric tumors. We aimed to investigate the correlation between the tissue expression of parkin and the clinical-pathological characteristics, and to determine if parkin can be used as a prognostic marker. We assessed immune histochemical analysis of parkin in five solid pediatric tumors. High tissue expression of parkin was associated with positive prognostic factors for astrocytoma’s and nephronblastomas, while in medulloblastomas and neuroblastomas; the same underlying aspect was associated with poor prognostic factors. Choroid plexus tumors showed no association. Parkin showed favorable behavior in patients with in astrocytoma’s and nephroblastomas. In medulloblastomas and neuroblastomas, results showed the opposite. Research may enable an analysis of the overall behavior of this molecule as a prognostic tool.