आणविक और आनुवंशिक चिकित्सा

Poly(N–Isopropylacrylamide–Co–Acrylic Acid) Smart Nanocarriers for Drug Release: A Study of Theophylline Delivery

Abstract

Álvarez–Bautista A, Mendizábal E, Duarte CMM and Katime I

Copolymeric nanoparticles of poly(N–isopropylacrylamide–co–acrylic acid) have been synthesized by inverse microemulsion polymerization. The obtained nanoparticles have been characterized by FTIR and DSC, to detect her molecular structure and glass transition temperatures respectively, by transmission electron microscopy (TEM) and quasielastic light scattering (QLS) to determine the sizes and size distribution of gels synthesized. The swelling of these nanogels has been studied in order to know their response at different pH and crosslinking agent concentration. These nanoparticles have subsequently been charged with a vasodilator drug (theophylline) to study the release–kinetics of the drug release at different pH. These nanogels have shown a controlled release at basic environment. After further biological viability studies this system could be used as smart carriers in nanomedicine.