आणविक और आनुवंशिक चिकित्सा

Identification of Thr241Met Polymorphisms of the XRCC3 Gene in People with Gastric Cancer in the Amazon Region, Brazil

Abstract

Lobato LL, Da Silva Cabra l S, Vanzeler TL, Do Nascimento RE, Picanço OM and Do Nascimento Rodrigues AS

XRCC3 Thr241Met polymorphism has been associated with cancer susceptibility. Studies have shown a relationship between Thr241Met polymorphism and gastric cancer. The present study was aimed at examining the presence of XRCC3 Thr241Met polymorphism in patients diagnosed with gastric cancer in the city of Macapá. We analyzed 150 DNA samples, of which 100 comprised the control group and 50 were case patients. Our findings revealed that 76% of case samples had the Thr/Met genotype (OR (CI 95% 54.29 (18.84-156.38) p ≤ 0.0001) whereas in the control group, the same genotype represented 7%. Also, most gastric cancer patients with XRCC3 241Met polymorphism were heterozygotes. Given the small sample size in this study, a larger number of patients will be analyzed.