Lewis Nixon*
The M-band and Z-disc are transversal structural features of cross-striated muscles that anchor and mechanically support the contractile apparatus and its minimum unit, the sarcomere. Proteins' capacity to locate and interact with these structural sarcomeric parts is an unavoidable requirement for proper myofbrillar apparatus construction and function. The M-band, in particular, is a well-known mechanical and signalling hub that deals with active forces during contraction, and its damage causes sickness and death. The assembly and interactions of the three key flamentous proteins in the region, primarily the three myomesin proteins, including their Embryonic Heart (EH) isoform, titin, and obscurin, are the focus of research on the M-band architecture.
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