Kyunghee K Song
A diagnostic test in a screening study detects a clinical condition of interest in its asymptomatic stage. Evaluating the diagnostic test in a screening study is a challenging task since a diagnostic test is evaluated based on its analytical and clinical performance. In order to evaluate clinical performance of a diagnostic test in a screening study, it is crucial to investigate clinical outcome studies such as survival studies. Furthermore, there are important biases to be considered in a screening study. In this paper, statistical issues associated with screening studies are discussed, and statistical adjustment for screening-related bias, which is called length bias, is presented. Both Vardi’s bias-adjusted nonparametric maximum likelihood estimator and linear combination estimators have shown to adjust length bias successfully, and generate bias-adjusted survival curve close to the true survival curve. Finally, some practical issues associated with early detection are also presented.
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