Jacqueline Maisonnave
Mesenchymal Stem Cells (MSCs) are potential therapeutical biological products, to be used in Veterinary Medicine and animal models, due to their attractive characteristics: multipotentiality, immunomodulation, angiogenesis, tissue regeneration, homing to areas of injury and antimicrobial effect. MSCs are found in every organ of the body and are able to maintain their undifferentiated state for long periods of time and differentiate to specialized cells. Initially the most common MSCs source was bone marrow (BM), but now a days the adipose tissue (AT) source, is more commonly used. Lately other sources are been studied as Umbilical cord derived MSCs (UC-MSCs) and dental pulp stem cells (DPSC). At our lab the AT MSCs are isolated by enzymatic method and UC & DP derived MSCs are isolated by overgrowth method. In 2010 a domestic animal MSCs biobank was created as well as the Regenerative Veterinary Medicine (RVM) Service at the Immunology Area of Veterinary School, University of Uruguay. Also in 2010 we created the First RVM International group at the University of Uruguay. At the Veterinary Teaching Hospital through the RVM service, we treated orthopedic problems (nonunion fractures, osteomyelitis, tendon, ligament and joint injuries), skin lesions and mucosal inflammation problems, in canines, felines and equines. These clinical cases treated with allogenic AT-MSCs and Platelet Rich Plasma (PRP) end up being Graduate Thesis (n:7). I will be presenting the evolution of these RVM treatments n domestic animals. Basic research as isolation, characterization and genetic studies of MSCs, as well as studies on the use of platelet lysate (PL) as substitute of FBS in MSCs culture, end up in MSCs (n:2) and PhD (n:1) thesis. Future studies will be done with UC-MSCs and DPSC as well as with limbal derived MSCs. Pluripotency markers have been detected in DPSC, therefore they can also differentiate into neurogenic cells.
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