परमाणु चिकित्सा एवं विकिरण चिकित्सा

Reirradiation in Head and Neck Cancer: A Curative Intent in Recurrence or Second Tumors

Abstract

Enrique Jurado Martín, Vladimir Suarezb, Ismael Herruzo Cabrera, Lourdes de la Peña, Gustavo Ossola Lentatia, Maria José Ortiz Gordillob and Jerónimo Pachon Ibañezb

Purpose: To assess the efficacy and safety of reirradiation in head and neck cancer and potential prognostic factors associated. Material and methods: Cohort study of patients treated with curative reirradiation for recurrence or second primary tumor. The analysis of RR is obtained prospectively from the database available at both centers. Statistical analysis was performed using the R Commander 2.0 software. Results: Between 2006 and 2013, 40 patients with head and neck carcinoma were reirradiated. The mean dose was 66.39 Gy. 35% of patients showed acute toxicity grade 3 or higher and 20.5% showed chronic toxicity grade 2 or higher. The median follow-up was 11 months. The overall survival at 2 years was 41%; disease free survival and locoregional control at 1 year was 35.9% and 41.1% respectively. The time between treatments and disease-free interval to death and local recurrence were statistically significant (p < 0.05); and the first treatment scheme to distant metastases.