जर्नल ऑफ क्लिनिकल रेस्पिरेटरी डिजीज एंड केयर: ओपन एक्सेस

Prevalence of Vitamin D Deficiency in Obstructive Sleep Apnea Disorder in Dubai, UAE

Abstract

Fatehrahman Shendi, Bassam Mahboub, Hassan Alhariri and Annie Soans

Purpose: Sleep disorders have become epidemic throughout the worldwide, at the same time due to Multiple social changes, the same thing can be said for the vitamin D deficiency disorders, including the use of air conditioning and sunscreen, have produced a world-wide epidemic of vitamin D deficiency, then taking in consideration the proposed concept that since vitamin D plays an important role in the brainstem control of sleep, which is supported by the presence of vitamin D receptors in same areas are considered to play a role in the initiation and maintenance of sleep, this relation may not be strong as causative association but presence of either may have worsening effect on the other. Methods: The aim of our study was to investigate the prevalence of between serum 25-hydroxy [25 (OH)] vitamin D levels and severity of disease in patients with OSAS, among the cosmopolitan (multi-national) population of Dubai, United Arab Emirates. Two hundred and sixty nine (269) patients were included in the study, all who were referred to the sleep clinic at Rashid hospital – Dubai health Authority, during the period of three years from 2012 to 2014. Serum 1-25 Di Hydroxy Chole Caciferaol (vitamin D), were evaluated. Results: Among the 148 patients who had OSA; those who were vitamin D deficient represent 16.1% of the Mild OSA group, 7.3% of the moderate OSA group and 7.9% of the Severe OSA group, while at the same time those who were vitamin D insufficient represent 29% of the Mild OSA group, 39% of the moderate OSA group and 31.6% of the Severe OSA group. Conclusions: When the severity of OSA increases, then vitamin deficiencies, becomes more pronounced(but not significant), Thus subjects with more severe OSA indices tended to present lower vitamin D levels; furthermore Vitamin D deficiency may play a role and/or worsen OSA’s. We need to study more OSA adverse outcomes on glucose metabolism, in relation to vitamin D deficiency & insufficiency, as may be considered for supplementation treatment.