जर्नल ऑफ़ टिश्यू साइंस एंड इंजीनियरिंग

Feedback Controlled Release of Alendronate from Composite Microparticles

Abstract

Matrali SSH and Ghag AK

Extended bone fractures or fractures coexisting with bone disorders can lead to non-unions where surgical intervention is required. Composite drug delivery systems are
being used increasingly more in order to treat such defects locally. Alendronate (ALD), a bisphosphonate extensively used in clinical practice to treat conditions such as
osteoporosis has been shown to assist bone fracture healing through its antiresorptive capacity. This study reports the development of a polymeric composite system for the
in situ delivery of ALD, which possesses enhanced encapsulation efficiency (EE%) and demonstrates controlled release over a 70 day period. ALD and calcium phosphate
(CaP) have been incorporated within poly (lactic-co-glycolic acid) (PLGA) microspheres giving rise to a 70% increase in EE% compared to a control system. Finally,
preliminary toxicological evaluation demonstrates a positive effect of the system on pre-osteoblastic cells over 72 hours.