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Epigenetics and Hematopoietic Stem or Progenitor Cells

Abstract

Yang Wang, Benjamin T. Moore, Xianhao Peng and Peng Xiao

The maintenance and differentiation of hematopoietic stem/progenitor cells (HSPCs) is a critical process of hematopoiesis that includes the formation of lymphoid lineage and myeloid lineage. Epigenetic regulation is mainly composed of DNA methylation, histone modifications, non-coding microRNA (miRNA) regulation and chromatin remodeling, which are essential for the maintenance and differentiation of hematopoietic stem/progenitor cells (HSPCs). This review details the epigenetic studies of four major epigenetic mechanisms in normal and aberrant HSPCs, as well as hematopoiesis.

अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।

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