Fred Y. Ye*, Lucy L. Xu, and Adam Y. Ye
It is necessary and useful to reveal the chromosomal distribution at whole-genome level. By studying the chromosomal distribution of human disease genes, we found that the known genes of single-gene diseases are significantly enriched in chromosome X, and depleted in 10p, 19q. And the genes of multi-gene diseases are significantly tended to be located in fewer chromosomes than random background. The chromosomal distribution at whole-genome level could promote future studies of human disease genes.
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