इम्यूनोबायोलॉजी जर्नल

Association between Vitiligo and Thyroid Autoimmunity in Jordanian Population

Abstract

Alawneh S, Ayman Abu Awad, Mamoon Athamneh, Salim Abdel Rahman, Mohammad Abu-Zaid, Omema D Abu-Alsondos and Nedal Alnawaiseh

Vitiligo is considered to be the most commonly acquired hypomelanosis. In this study, we investigated some of the issues with regards to Vitiligo and its association with autoimmune thyroiditis. In this case-control study, thyroxine (FT4), triiodothyronine (FT3), and thyroid stimulating hormone (TSH) were measured in 130 patients with vitiligo and in 99 healthy volunteers. Also, we compared the frequency of thyroid autoantibodies (anti-Tg, thyroid peroxidase antibody, and anti-TPO) in the same groups.

Results: Showed that thyroid functional abnormalities were found in 6 (18.18%) patients. Anti-Tg and anti-TPO were positive in 115 (88.5%) patients respectively. In the control group, only nine subjects (9.1%) had abnormalities in thyroid hormonal condition, and two subjects had positive thyroid autoantibodies compared with the control group, and the frequency of both anti-Tg and anti-TPO was significantly higher in those with vitiligo.

Conclusion: This study showed a significant association between vitiligo and thyroid autoimmunity and the tests to detect thyroid autoantibodies that are appropriate in patients with vitiligo.