रासायनिक विज्ञान जर्नल

An Efficient One Pot Synthesis and Biological Screening of Some Pyrazole Based Heterocycles

Abstract

Archana D. Jadhav1, Pankaj U. Barhate and Ayesha N. Durrani

Present work deals with the preparation of some Pyrazole derivative salts which was prepared by using different kinds of aldehydes and hydrazine derivatives by using alkoxide as a base and using the 1,3- dicarbonyl compound like ethyl acetoacetate at room temperature. The reaction mixture was stirred on magnetic stirrer for about 10 to 20 minutes till colour change is observed and then product is separated by using organic solvent. The product obtained was converted to sodium salt of Pyrazole derivative by base hydrolysis. The entire synthesized compound was tested for their antibacterial activity against the Gram-positive and Gram-negative strains of bacteria. The investigation of antibacterial screening data revealed that most of the tested compounds showed moderate to good antibacterial activity.