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आयतन 11, मुद्दा 10 (2021)

शोध आलेख

Response of Blood Eosinophils in Lactating Crossbred Cows Fed with Bamboo Leaves as a Replacement to Pasture Hay in Central Ethiopia

Beksisa Urge*, Temegen Kasa, Eyob Gebregziabhear, Getu Kitaw, Yigardu Mulatu

The objective of this experiment was to evaluate the effect of feeding bamboo leaf alone or in mixture with hay as basal diet on physiological and Blood eosinophil values in high grade crossbred milking cows. Five milking cows were grouped randomly into five treatments consisting of hay and bamboo leaves at the proportion of 100:0 (T1), 75:25 (T2), 50:50 (T3), 25:75 (T4) and 0:100% (T5) respectively. A prospective study was undertaken to study the effects of bamboo leaves on the response of eosinophils in experimental crossbred cows. In this experiment, mean rectal temperature of crossbred milking cows that had fed 25% (T2), 50% (T3) and 75% (T4) inclusion of bamboo leaves replacement over cows that received the control diet (T1) was 39.06 ± 0.64, 38.02 ± 0.70 and 39.04 ± 0.62 respectively. Similarly, mean blood eosinophil responses (55.33±3.90), mean packed cell volume indices (23.75 ± 0.66) and milk yield (7.9 ± 0.25) had dropped significantly (p<0.05) in crossbred cows that were fed with bamboo leaf replacement of the pasture hay at the ratio of 100% (T5). Mean Milk yield (8.3± 0.23), mean packed cell volume volume indices (30.5 ± 2.10) and mean blood eosinophils (118.75 ± 9.71) were significantly (P<0.05) increased for crossbred cows that had fed bamboo leaf at the ratio of 25% (T2) and 50% (T3) as compared to T1 values. Change of body weight of cows that were fed with 75% (T4) was significantly declined and lost in 100% (T5) which was negatively correlated with complete substitution (p<5%). The Eosinophil index of milking cows was generally greater in T2 and T3 values. Outputs of the experiment showed that Bamboo leaf supplementation had linearly improved blood eosinophil responses significantly (p<5%) at 25 percent and 50 percent inclusion levels over crossbred cows that had received the control diet (T1). Based on the result of this experiment, blood eosinophils of crossbred cows were effective and responsive when bamboo leaves had replaced the pasture hay at the ratio of 25% (T2) and 50%(T3) levels. On the other hand, bamboo leaf supplementation at the rate of 75% (T4) and 100%(T5) inclusion levels had resulted in poor performances of blood eosinophils and depressed milk yield that had adversely induced profuse diarrhea, weight loss, gait disorders, convulsions, toxic and other adverse effects in the experimental lactating cows. In conclusion, Bamboo leaves had better blood response values as compared to pasture hay in this experiment and hence can be a good substitute to hay at the rate of 25% and 50% in the long dry season when conventional roughages are in short supply without any adverse health effect on the cows.

समीक्षा लेख

A Review on Different Synthetic Route and the Medicinal Aplications of 2-(3-(Dimethylamino)Propyl) Isoindoline-1,3-Dione Derivatives

Rajesh Kumar Das*, and Sahin Reja

2-(3-(Dimethylamino)Propyl)Isoindoline-1,3-Dione (DAPID) derivatives have been obtained by the reaction of the phthalic acid anhydride derivatives with N, N dimethyl propyl amine derivatives. The yield of DAPID type derivative was 60% by classical way which was carried out in our laboratory. But when this reaction was carried out by modern way i.e. microwave enhance method, then the yield was 85% to 91% with short time. 3-(1,3-dioxoisoindolin-2-yl)-N,N-dimethylpropan-1-ammonium perchlorate (DIDAP) derivatives have been obtained by the reaction of 2-(3-(Dimethylamino)Propyl)Isoindoline-1,3-Dione (DAPID) derivatives with salt. The DIDAP compound was synthesized in a different route followed by able to show it’s excellent anticancer activity against hepatomas Hep G2 Cell line.

संपादकीय

Reorganizations in the Field of Medicinal Chemistry

Norman Doorenbos

Medicinal Chemistry is an educational magazine offers with the aspects of Chemistry, Pharmacoanalysis and the chemical evaluation of compounds withinside the shape of like small natural molecules which includes insulin glargine, erythropoietin, and others. It additionally allows in growing new chemical entities from current compounds which can be of medicinal and healing impact. The procedure entails seclusion and identity of the entities and their possibly impact at the precise goal and may consist of a computational or artificial statement of the underlying agents.

शोध आलेख

Screening of semicarbazones as anticonvulsant agents

Ajay kumar garg, Ranjan Kumar Singh, khushboo srimali

Objective: The principal objective of the present investigation was the preparation of several analogs to further evaluate the binding site hypothesis. Aryl semicarbazides have also been reported to display excellent anticonvulsant activity in mice and rats. Method: In this project, the synthesis of semicarbazone derivatives was carried out. All molecules were synthesized using the common starting material –aniline. In all compounds, an intermediate was first formed by substituted phenyl urea using substituted aniline and potassium cyanate, and then it was hydrolyzed to get substituted phenyl semicarbazide, which was directly coupled with ketones. All the synthesized compounds were biologically screened for their anticonvulsant activity by MES method. Result: Standard error mean was calculated with the respect of standard and control drug, Phenytoin sodium (25mg/kg.) and DMSO. The synthesized semicarbazone were characterized by using IR Spectroscopy. One another representative molecule compound was characterized using 1H NMR Spectroscopy. Conclusion: It can be concluded that designed semicarbazones were synthesized and characterized successfully. After synthesis of designed semicarbazones compounds were evaluated for anticonvulsant activity. Finally, two compounds have shown better activity in comparisons to the other molecules.

संपादकीय

Assimilation, Dispersion, Metabolism and Excretion

Kejia Jessy

Drug design, frequently alluded to as sane medication plan or simply rational design, is the innovative interaction of discovering new drugs dependent on the information on a natural objective [1]. The medication is most regularly a natural little particle that initiates or represses the capacity of a biomolecule like a protein, which thus brings about a restorative advantage to the patient. In the most fundamental sense, drug configuration includes the plan of particles that are integral fit and charge to the bio molecular focus with which they communicate and in this manner will tie to it. Medication plan regularly but not really depends on PC demonstrating strategies.

लघु संचार

Clinical Pharmaceutical Chemistry

Kejia Jessy

Clinical drug science is a claim to fame part of compound sciences, which comprises of restorative science with extra preparing in clinical parts of translational sciences and medication. Normally this includes comparable chief preparing as in everyday medication, where assessment of and connection with the patients are a fundamental piece of the preparation. Regularly understudies in clinical drug science utilize similar educational program as clinical understudies, however work in therapeutic and natural science after and during the hypothetical/ early clinical examinations [1]. In clinical drug science the point is to comprehend natural changes and cycles related with synthetic substances inside the human body, and how those cycles can be affected with changes in compound constructions.

शोध आलेख

Analgesics and Anticancer of Some Synthesized 2-Benzimidazole Derivatives

Ahmed Hussein, Helmy M Sakr, Rezk R Ayyad, Kazem Mahmoud, Ahmed M Mansour and Ahmed G Ahmed

This work, contain some new compounds from benzimidazole derivatives, which synthesized by condensation of Orthophenylene diamine and Carbon disulfide resulting 2-Mercapto-benzimidazole which treated by alcoholic potassium hydroxide forming potassium salt of 2- mercaptobenzimidazole which reacts with different substances (alkyl chloroacetates, chloroacetic chloride, alkyl halides) also the ethoxy carbonyl methyl thiobenzimidazole reacts with different amines in addition to chloromethyl benzimidazole which resulted from the reaction between orthophenylene diamine and chloroacetic acid, which reacted with different amines. The synthesized compound tested as analgesics and anticancer activity the new derivatives revealed moderate, strong and very strong analgesics and moderate and strong anticancer activity.

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