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Thyroid Disorders 2016 - Next generation sequencing of Thyroid neoplasms to determine mutational status

Abstract

Orla Sheils

The anticipation for patients with thyroid carcinoma is commonly reliant on age and tumor stage at time of determination. In any case, the natural forcefulness of individual tumors can’t generally be anticipated from the underlying clinical highlights, making it troublesome reliably to recognize patients who will kick the bucket from their ailment. Additionally, the event of vague lymphocytic thyroiditis of changing seriousness nearby thyroid tumors is every now and again watched. Hazard factors for the advancement of thyroid malignant growth incorporate radiation presentation, physical and germ line hereditary transformations. Regular transformations that go before the improvement of thyroid carcinoma focus on the mitogen-enacted protein kinase (MAPK pathway) and incorporate BRAF, RET/PTC and RAS. We utilized a NGS sequencing approach for equal cross examination of the nearness of physical transformations in tests from 82 patients.

अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।

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