Musa Basheer Mansour1* and Sara Elsheikh Ahmedana2*
Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) initially used to treat hypertension. They can use to treat diabetes, chronic renal insufficiency (CRI)(RI), congestive heart failure (CHF)(HF) and myocardial infarction (MI). They recorded to have some adverse effects (AEs) such as adverse renal failure (RF) due to the lack of appropriate timelines monitoring scheme. The following systematic review (SR) will focus on the AEs of the administration of ACEIs/ARBs without appropriate timelines monitoring on adult patients as the specific population under study as per the prevailing literature provides. The data sources include a search for English language literature in the Cochrane database (2015-2019), MEDLINE and American Heart Association Journal Database (AHA). The search terms in the above databases included ACEIs /ARBs, adults, clinical trials, laboratory trials, random trails, humans and timeline monitoring. The study selection included literature with random control trials of patients with the above diseases and how the appropriate monitoring of ACEIs/ARBs had any effects on the angiotensin system in adults. The data extraction is based on 8 sources while keeping in mind the data fields used and the quality of the studies conducted. The data synthesis criteria observed a pool of patients larger than 50,000 included in each study that was put under the administration of ACEIs/ARBs for a year while noting the appropriate timelines monitoring of ACEIs/ARBs on the potassium and creatinine and how they affect the patients if they are not properly monitored. The SR of these laboratory studies confirms that under appropriate timelines monitoring of the administration of ACEIs/ARBs, apart from treating the above diseases have very limited AEs on the renin-angiotensin-aldosterone system of the patients under observation.
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