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Synthesis, Biological and Anti-tumor Evaluation of Some New Nucleosides Incorporating Heterocyclic Moieties

Abstract

Fekria MA Soliman, Nadia TA Dawoud and Rehab M Hamza

1,3-diaryl-1-propen-3-ones 1a-h, were used as building blocks for a large range of nucleoside analogs incorporating five and six-membered heterocyclic rings. Heterocyclic compounds incorporating aromatic moieties (2-11) and their N-nucleoside analogs (13-20) were synthesized. New compounds were evaluated for their potential antimicrobial, antifungal activities and for their in vitro cytotoxic activity against three cell lines: human breast cancer cell line (MCF- 7), colon carcinoma cells (HCT) and human epidermid/arynx carcinoma cell line (HEp2).

अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।

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