..

जर्नल ऑफ़ क्लिनिकल केस रिपोर्ट्स

पांडुलिपि जमा करें arrow_forward arrow_forward ..

Seroconversion of Hbsag in Melanoma Patient with Hepatitis B Treated with Checkpoint Inhibitors: A Case Report

Abstract

Xizhi Wen, Ya Ding, Baoyan Zhu, Dandan Li, Jinjin Li, Yao Wang and Xiaoshi Zhang

Based on remarkable and sustained antitumor activity, the anti-CTLA-4 antibody ipilimumab, and anti-PD1 antibodies nivolumab and pembrolizumab have been approved for treatment of advanced melanoma. As checkpoint blockade is associated with potentially serious immune-related adverse events, including autoimmune hepatitis, clinical trials evaluating these agents have excluded patients with chronic hepatitis B virus infection. Herein, we describe one patient with advanced melanoma and concomitant HBV infections experiencing seroconversion of HBsAg after treatment with combination of PD-1 and CTLA-4 blockade.

अस्वीकृति: इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।

इस लेख का हिस्सा

में अनुक्रमित

arrow_upward arrow_upward