इम्यूनोकैमिस्ट्री और इम्यूनोपैथोलॉजी

Incidence and Severity of COVID-19 in Relation to Anti-receptor-binding Domain IgG Antibody Level after COVID-19 Vaccination in Kidney Transplant Recipients

Abstract

Tetasurae Ahreins*

Kidney Transplant Recipients (KTRs) are known to be at increased risk of severe outcomes from COVID-19 due to immunosuppression. With the emergence of COVID-19 vaccines, understanding the incidence and severity of breakthrough infections in KTRs and their association with anti- Receptor-Binding Domain (RBD) IgG antibody levels is critical for optimizing vaccination strategies in this vulnerable population. In this study, we investigated the relationship between anti-RBD IgG antibody levels after COVID-19 vaccination and the incidence and severity of COVID-19 in KTRs. A cohort of KTRs who received COVID-19 vaccination was monitored for breakthrough infections and anti-RBD IgG antibody levels were measured at regular intervals post-vaccination. Our findings provide insights into the effectiveness of COVID-19 vaccination in KTRs and highlight the importance of monitoring antibody responses for guiding vaccination strategies in immunocompromised individuals.