Ahmad Mohammad Khattab* and Hikmat Yakub
Background: Syrian Hamsters are considered prime animal models used in numerous experimental research and applications especially in the field of dentistry. Studies on Syrian hamsters have shown their exceptional regenerative abilities of incisors after extraction. Isolating and identifying cells responsible for the constant regeneration of the incisors, determining their unique properties, and confirming their ability to differentiate into ectoderm and mesoderm derived cells. Exploring their capabilities to construct cellular cultures in sufficient numbers and identifying the proper cellular markers is an extremely important issue.
Methods: 15 Syrian Hamsters were distributed evenly into three Main groups plus a control group. Control group was sacrificed in order to obtain a sound Morphological structure in the incisor region. Specimens in Main groups were gradually sacrificed to monitor the progress of the regeneration process within the next days following extraction on the first, fifth, and tenth day respectively.
Results: Results confirmed the presence of lymphoblastic lengthening encased inside the bone cavity consisting of active homogenous cell cultures. These cells can proliferate and differentiate forming the pulp, dentin, cementum, and periodontal ligaments. This was confirmed with immunohistochemical markers proving these cells are in fact adult stem cells in the periodontal tissues.
Conclusion: Regeneration process within the bone cavity happened fairly quickly in hamsters, incisor regeneration after extraction took less than one week, which provides adequate conditions to monitor the regenerative process within the cavity after extracting incisors in hamsters.
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