Medhi B, Pawan K Singh, Bansal Y S and Setia P
The incident of drug related medico legal cases are increasing day by day. In Forensic Medicine there is a need of frequent requirement of estimation of dose size administered or ingested by deceased, based on either postmortem blood level or concentration of drug in urine. In an ideal situation creatinine clearance should be evaluated than it is corrected according to age, sex and body surface area. Postmortem changes begin at cellular level with the onset of ischaemia. Depending on duration of ischaemia structure and function of organs and tissue gradually deteriorate which influence the distribution of drugs in the body fluids and tissues. For estimation of drug concentration of deceased, there is need to consider the postmortem redistribution phenomenon. De ceased drug concentration may not reflect the actual concentration at the time of death, similarly there is possibility that miss calculation from deceased blood level if it is not judiciously used to simulate the dose versus toxicity relationship. In this article authors have emphasis on various aspect of co-relation of drugs level following death and different factors that influence while predicting actual drug concentration for medico legal drugs related cases.
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