Sooho Choi, Ji Hyun Kim, Min Kyung Song, Eun-Sun Kim, Youn-Jung Kim and Jeong Hoon Kim
CXXC5 negatively regulates the Wnt signaling pathway by binding to the Wnt signaling component protein disheveled (Dvl). The Dvl protein comprises three domains: the DIX domain, the DEP domain, and the PDZ domain. The PDZ domain binds to the CXXC5 zinc finger domain. We prevented the CXXC5 effect by using a DNA aptamer (WD-Aptamer) that binds to the Dvl1_PDZ domain. The inhibitory effect of CXXC5 was confirmed through tests of cell proliferation in HaCaT cells and in vivo experiments using mice.
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