Huijie Shi, Lei Zhang, Yanjun Qu, Lifang Hou, Ling Wang and Min Zheng
Objective: To investigate the expression significance of inhibitor of DNA binding (Id)-1, Id-2 and Id-3 mRNAs in breast cancer patients, and explore the correlation between sonographic characteristics, histological grades and expressions of Id-1, Id-2 and Id-3 mRNAs.
Methods: The expressions of Id1-3 mRNAs in 62 breast cancer patients and 49 normal controls were examined by using real-time fluorescent quantitative reverse transcription polymerase chain reaction (RT-FQ-PCR). The correlations between sonographic characteristics, histological grades and expressions of Id1-3 mRNAs were analyzed with one-way ANOVA.
Results: Id-1 and Id-3 mRNA were higher expressed in breast cancer patients than those in normal control cases (Id-1: 0.0141 ± 0.01025 versus 0.0075 ± 0.00309, p=0.0001; Id-3: 0.0139 ± 0.01029 versus 0.0078 ± 0.00312, p=0.005), while expression of Id-2 mRNA was lower (Id-2: 0.0195 ± 0.01299 versus 0.0275 ± 0.01401, p=0.033). Along with the increase in histologic grades, Id-1 and Id-3 mRNA expressions in breast cancer tissue showed an increase tendency, however, Id-2 showed an opposite expression pattern with Id-1 and Id-3. The expression of Id-1 was higher in patients with keloid-like and hyperechoic halo, while Id-3 mRNA was highly expressed in patients with keloid-like and peripheral catheter expansion under ultrasonography.
Conclusion: Expression levels of Id-1 to 3 mRNAs are highly correlated with histological grades and sonographic characteristics of breast cancer.
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