Xuhao Song*
With 906,000 newly diagnosed cases worldwide in 2020, hepatocellular carcinoma is the sixth most common malignant tumour and the third leading cause of cancer-related deaths. The prevalence of HCC varies by ethnicity, with the majority of patients suffering from chronic infections of the hepatitis B and C viruses, metabolic-dysfunction-associated fatty liver disease, or alcoholic steatohepatitis. MAFLD, formerly known as nonalcoholic fatty liver disease, is characterised histologically by hepatocyte steatosis, steatohepatitis, Mallory's body, and fibrosis. MAFLD currently affects 30% of the global population, despite the fact that only 5% of patients will progress to MAFLD-related fibrosis or HCC. Although chronic HBV infection remains a major cause of HCC in China, MAFLD-related primary liver cancer has increased.
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