Sachin Chandrakant Deorukhkar*, Shahriar Roushani and Deepika Bhalerao
Background: Recent literature on invasive candidiasis clearly documents a shift towards non albicans Candida (NAC) species. A number of risk factors have been identified for candidemia. However the search through available literature has revealed paucity of data regarding differences between the C. albicans and NAC spp. candidemia.
Objective: The aim of this study was to investigate the epidemiology of candidemia and further analyze the risk factors, species distribution and antifungal susceptibility profile of NAC spp.
Results: Candida spp. was fifth among the leading causes of Blood stream infection. Predominance of NAC spp. was noted. C. tropicalis followed by C. glabrata were the major Candida isolates. ICU stay was the major risk factor associated with candidemia. Patients with candidemia due to NAC spp. were less likely to have diabetes compared those due to C. albicans. ICU stay and fluconazole prophylaxis/treatment were identified as significant risk for candidemia due to NAC spp. Azole resistance was significantly high in NAC spp. Conclusion: The emergence of NAC spp. highlights the importance of species identification along with antifungal susceptibility testing for institution of most appropriate antifungal drug.
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