जर्नल ऑफ़ हाइपरटेंशन: ओपन एक्सेस

Association Study of Single-Nucleotide Polymorphisms on Chromosome 1p13, 1p32, 9p21 and 19p13 with Cardiovascular Diseases in Chinese Han Population: A Case-Control Study

Abstract

Jin Guo, Yitian Feng, Habin Li, Feng Zhang, Yanxia Luo, Xiuhua Guo and Jialin Hu

Objectives: Previous research discovered single nucleotide polymorphism (rs2383206 and rs2383207) on chromosome 9p21 that is associated with coronary heart disease in a Chinese population. However, few data are available on the association of other single nucleotide polymorphism with cardiovascular disease in a Chinese population. This study aimed to determine whether the single nucleotide polymorphisms on chromosome 1p13, 1p32, 9p21 and 19p13 were associated with coronary artery disease in a Chinese population.

Methods: We conducted a case-control study. Cases were coronary artery disease (n=670) between 2010 and 2015. Controls (n=1340) were randomly selected and frequency matched to cases on age and gender. All of the participants were selected to study 18 single nucleotides using allele-specific real-time polymerase chain reaction method.

Results: Four single nucleotides in 9p21, two single nucleotides in 1p13 and one single nucleotide in 1p32 were associated with cardiovascular disease risk in Chinese population (Global P value for multiple logistic regression, <0.0001, respectively). rs10757274 showing the strongest association with cardiovascular disease. GG carriers of four SNPs (rs10757274, rs2383206, rs10757278 and rs1333049) in 9p21 had higher risk (Odds ratio=1.40, 95% Confidence interval: 1.10-1.79; Odds ratio=1.33, 95% Confidence interval: 1.04-1.69; Odds ratio=1.35, 95% Confidence interval: 1.07-1.72; Odds ratio=1.34, 95% Confidence interval: 1.06-1.71).

Conclusion: rs10757274, rs2383206, rs10757278 in 9p21, rs562556 in 1p32, and rs646776 in 1p13 may serve as a novel genetic marker for the risk of significant cardiovascular disease in Chinese Han population.