Daniela Pankova and Eric O Neill
Population of cancer stem cells in solid tumors represents a major factor of resistance to conventional therapy that influences patient survival. We recently identify RASSF1A as a novel regulator of cancer stemness that plays a key role in regulation of mechanical properties provided by ECM in lung cancer. We showed that epigenetic loss of RASSF1A promotes YAP1 nuclear accumulation which, via P4HA2 expression, drives ECM remodeling associated with Cancer Stem Cell (CSC) plasticity during malignant carcinogenesis.
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